The Pharma 16 Twin-Screw Extruder is ideal for pilot-scale, continuous HME or TSG processes used for research, development or production in the pharmaceutical industry. Companies can bring products to market faster and with high quality by developing a continuous process for solid dosage forms compared to a batch process. Effects of pilot-scale process conditions on drug formulations for drug delivery and pharmaceutics can easily be studied using the Pharma 16 Twin-Screw Extruder. Pharma 16 Twin-Screw Extruder highlights: 2-in-1 process design – quickly disassemble parts for easy cleaning and process switching from HME to TSG. Simple continuous process integration – plug-and-play functionality with upstream and downstream process equipment (e.g., feeders, chill rolls, pelletizers, dryers, etc) simplifies production line design. Less optimization time, cost and effort – extruder process parameters are scaleable to larger Thermo Scientific extruders due to geometric similarity with minimal use of expensive ingredients.
Pharma 16 Twin-Screw Extruder
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Rapidly develop pharmaceutical formulations and adopt continuous processing methods using the Thermo Scientific™ Pharma 16 Twin-Screw Extruder. The Pharma 16 Twin-Screw Extruder can switch between continuous hot melt extrusion (HME) or wet granulation (TSG) with ease. Optimize drug process development parameters with less time and effort than batch processes and easily scale-up to larger Thermo Scientific™ extruders with using minimal amounts of expensive APIs and excipients.
| Max. Speed |
1000 rpm |
|---|---|
| Speed Range |
10 to 1000 rpm |
| Electrical Requirements |
400 V 3Ph +N + PE (± 10%) |
| IP Rating |
IP 54 |
| Pressure |
150 bar |
| Throughput |
HME: 0.5-5 kg/h / TSG: 1-15 kg/h (depending on formulation) |
| Max. Torque |
18 Nm/Screw |
| Barrel Zones |
7 barrel zones (1st zone permanent cooled) + 1 die heater |
| Dimensions (L x W x H) |
1750 x 610 x 1220 mm |
| Barrel Length L/D |
40:1 L/D |
| Length (English) |
Screw length: HME L/D = 40 (40 x 16 mm = 640 mm), TSG L/D = 40.75 (40.75 x 16 mm = 652 mm) |
| Temperature Range (Metric) |
HME: 10 to 300°C, TSG: 10 to 100°C |
| Barrel |
Barrel Length 40:1 L/D |
| Center Line Spacing |
1050 mm |
| Weight (Metric) |
350 kg |
| Unit Size |
Each |
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